Gastroenterology

Pantoprazole DSR Formulations: Enteric-Coated Pellets vs Sustained Release Technology

30 Oct 2026 • 7 min read • Riomedica Procurement Editorial

Pantoprazole sodium and Domperidone sustained-release capsules (DSR) are among the highest-volume gastroenterological formulations prescribed across India.

1. Enteric-Coated Pellet Technology

Pantoprazole is acid-labile and degrades in gastric acid. Enteric-coated pellets protect the active PPI through the stomach, releasing it selectively in the alkaline pH of the duodenum.

2. Dual-Release Prokinetic Kinetics

The formulation combines 10mg immediate-release Domperidone for prompt antiemetic relief with 20mg sustained-release Domperidone for all-day prokinetic motility regulation.

3. Commercial Packaging Standards

Riomedica supplies PANRIO-DSR in high-barrier 10x10 ALU-ALU packaging with tamper-evident foils to prevent moisture absorption in humid climates.

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Frequently Asked Questions

Why is Pantoprazole formulated in enteric-coated pellets?
Pantoprazole degrades in gastric stomach acid. Enteric polymers protect the active molecule until it reaches the alkaline duodenum.
What is the clinical role of Domperidone in DSR formulations?
Domperidone acts as a prokinetic agent, accelerating gastric emptying and eliminating gastroesophageal reflux symptoms.
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